USC vs. Colorado: Betting odds, lines, picks against the spread

It’s no surprise that oddsmakers will see the USC Trojans (8-1, 6-1 in the Pac-12) as big 34-point favorites when they defeat the Colorado Buffaloes (1-8, 1- 5) received Friday in the coliseum.

USC is No. 8 in the latest College Football Playoffs rankings and hopes to have a way into the “Final Four” if they are No. 12 UCLA, No. 20 Notre Dame and then possibly No. 6 Oregon in the Pac-12 championship game on Friday, December 2nd, in Las Vegas.

But first the Trojans have to get down to business (and “style points” wouldn’t hurt) against Colorado, as they’ll be relying on quarterback Caleb Williams (2,742 passing yards, 28 TDs, only 1 INT). Williams is the fourth betting option in DraftKings’ Heisman Trophy odds at 9-1.

Despite the spread being so wide, late Wednesday morning 59% of the bets and 79% of the money were on the Trojans at DraftKings. Updated betting splits for all major sports can be found on the dedicated VSiN page.

USC covered a wide span like this as a 32.5-point favorite as it beat Rice 66-14 in the opening game, but the Trojans couldn’t find wins over Arizona State (-24.5 at 42-25), Arizona ( -) achieve. 14 in 45-37 win) and Cal (-21 in 41-35), so let the bettor beware when the spread is that wide. Hope for USC supporters is the fact that Colorado is only 2-7 ATS despite usually getting plenty of points, including a 49-10 loss to Oregon last Saturday as 31.5-point house dogs.

The over/under opened at 64 points and was settled down to 66 with 44% of the bets and 61% of the money on the over at DraftKings, with the Trojans expected to take most of the score as the expected score on a game is similar is this with a spread of 34 points and a total of 66 points would be USC 50, Colorado 16.

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